Roberta Fruttero Selected Research

1,2,5-oxadiazole 2-oxide

1/2021	Tuning NO release of organelle-targeted furoxan derivatives and their cytotoxicity against lung cancer cells.
1/2017	New furoxan derivatives for the treatment of ocular hypertension.
11/2016	Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.
10/2015	NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
1/2015	A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
7/2011	Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.
1/2009	Effects of nitric oxide donor antioxidants containing the phenol vitamin E substructure and a furoxan moiety on ischemia/reperfusion injury.
4/2007	NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization.
7/2005	The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities.

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Roberta Fruttero Research Topics

Disease

15	Neoplasms (Cancer) 01/2021 - 09/2011
3	Cardiotoxicity 01/2019 - 07/2005
3	Edema (Dropsy) 07/2013 - 03/2008
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2009 - 04/2007
2	Adenocarcinoma of Lung 01/2021 - 01/2018
2	Osteosarcoma (Osteogenic Sarcoma) 02/2019 - 01/2019
2	Necrosis 01/2018 - 07/2008
2	Atherosclerosis 01/2016 - 04/2007
2	Cerebral Malaria 10/2015 - 05/2011
2	Colonic Neoplasms (Colon Cancer) 09/2014 - 07/2011
2	Reperfusion Injury 08/2012 - 01/2009
1	Virus Diseases (Viral Diseases) 04/2022
1	COVID-19 04/2022
1	Lung Neoplasms (Lung Cancer) 01/2021
1	Adenocarcinoma 12/2020
1	Sickle Cell Anemia (Hemoglobin S Disease) 06/2018
1	Phototoxic Dermatitis (Phototoxicity) 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2018
1	Glaucoma 10/2017
1	Ocular Hypertension (Glaucoma, Suspect) 01/2017
1	Starvation 01/2017
1	Tuberculosis (Tuberculoses) 11/2016
1	Pain (Aches) 01/2016
1	Ischemia 01/2015
1	Ovarian Neoplasms (Ovarian Cancer) 09/2014
1	Leishmaniasis 08/2014
1	Breast Neoplasms (Breast Cancer) 10/2013
1	Inflammation (Inflammations) 04/2013
1	Rheumatoid Arthritis 02/2013
1	Lymphoma (Lymphomas) 10/2012
1	Hypoxia (Hypoxemia) 08/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2012
1	Infarction (Infarctions) 01/2009
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2009

Drug/Important Bio-Agent (IBA)

10	Pharmaceutical PreparationsIBA 12/2020 - 01/2013
9	1,2,5-oxadiazole 2-oxideIBA 01/2021 - 07/2005
8	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2020 - 07/2011
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 04/2007
5	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2020 - 01/2018
3	Liposomes (Liposome)IBA 12/2020 - 01/2018
3	Nitric Oxide DonorsIBA 01/2015 - 01/2009
3	CarrageenanIBA 07/2013 - 03/2008
2	Biological ProductsIBA 11/2019 - 08/2019
2	AnthracyclinesIBA 02/2019 - 01/2013
2	Proteins (Proteins, Gene)FDA Link 02/2019 - 02/2013
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2016 - 04/2007
2	AntioxidantsIBA 01/2009 - 04/2007
1	Antiviral Agents (Antivirals)IBA 04/2022
1	Cysteine (L-Cysteine)FDA Link 01/2021
1	SolutionsIBA 01/2021
1	Gemcitabine FDA Link 12/2020
1	PolymersIBA 01/2020
1	AcridinesIBA 01/2020
1	Antineoplastic Agents (Antineoplastics)IBA 01/2020
1	4,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)IBA 11/2019
1	Hyaluronic Acid (Hyaluronan)IBA 01/2019
1	OxidesIBA 06/2018
1	Peroxynitrous Acid (Peroxynitrite)IBA 01/2018
1	triphenylphosphoniumIBA 01/2018
1	BromidesIBA 01/2018
1	Superoxides (Superoxide)IBA 01/2018
1	1,2,3,4-tetrahydroisoquinolineIBA 01/2018
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2018
1	carbomerIBA 10/2017
1	IronIBA 01/2017
1	CarbonIBA 01/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Thromboxane Receptors (Thromboxane Receptor)IBA 01/2016
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2016
1	Singlet OxygenIBA 01/2016
1	ProstaglandinsIBA 01/2016
1	Thromboxane A2 (A2, Thromboxane)IBA 01/2016
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2016
1	artemisinin (artemisinine)IBA 10/2015
1	artenimol (dihydroartemisinin)IBA 10/2015
1	EdaravoneIBA 01/2015
1	multidrug resistance-associated protein 1IBA 09/2014
1	liposomal doxorubicin (Doxil)FDA Link 09/2014
1	Adenosine Triphosphate (ATP)IBA 10/2013
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 10/2013
1	ProdrugsIBA 07/2013
1	OxalatesIBA 07/2013
1	Benzoates (Benzoate)IBA 07/2013
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2013
1	RoscovitineIBA 04/2013
1	CalciumIBA 02/2013
1	CitrullineIBA 02/2013
1	EnzymesIBA 02/2013
1	Arginine (L-Arginine)FDA Link 02/2013
1	ThymopentinIBA 10/2012
1	AmidesIBA 08/2012
1	CarnosineIBA 08/2012
1	ChemokinesIBA 09/2011
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2011
1	Reactive Nitrogen SpeciesIBA 09/2011
1	Amodiaquine (Camoquin)FDA Link 05/2011
1	Vitamin E FDA LinkGeneric 01/2009

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 01/2020 - 01/2018
2	Therapeutics 04/2022 - 12/2020
1	Immunotherapy 09/2011